Craniosynostosis refers to the premature fusion of one or several calvarian sutures. For transient skull distortion during birth, as well as to facilitate growth of the brain, the seven bones of the calvarian are separated by six major calvarian sutures (Figure 1). The sutures function as growth centers. The center of the suture deposits proliferating cells, which gradually undergo osteogenetic differentiation. Migration towards the skull bone results in growth of the cranial vault. This is an important requisite to allow the brain quadrupling its volume during the first two years of life. The posterior fontanel will close first at an age of two months. The metopic suture will close next within the first year of life, followed by closure of the anterior fontanel at the age of two years. Although the other sutures only close in adulthood, they lose their function in skull growth after the age of six years.

Additional Metadata
Keywords calvarian sutures., craniosynostosis, skull growth
Promotor I.M.J. Mathijssen (Irene) , S.E.R. Hovius (Steven)
Publisher Erasmus University Rotterdam
Sponsor BlooMedical benelux NV, Esser Foundation, JVPC, KLS Martin Group, Kortjakje Zondagsschool voor plastische chirurgie, Medical Qua, NVPC, Stichting Hoofdzaak, Van Wijngaarden Medical Drukkleding-Revalidatiehulpmiddelen, ZEISS
ISBN 978-94-6169-346-4
Persistent URL
Driessen, C. (2013, March). Syndromic craniosynostosis: sleeping with the enemy. Erasmus University Rotterdam. Retrieved from

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4. Beschouwing.pdf Final Version , 742kb
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2. Inhoudsopgave.pdf Final Version , 259kb
5. Conclusie.pdf Final Version , 127kb
CD boekje.pdf Final Version , 106kb
1. Titelpagina.pdf Final Version , 75kb
Stellingen Driessen.pdf , 29kb