The lymph nodes (LNs) and spleen have an optimal structure that allows the interaction between T cells, B cells and antigen-presenting dendritic cells (DCs) on a matrix made up by stromal cells. Such a highly organized structure can also be formed in tertiary lymphoid organs (TLOs) at sites of infection or chronic immune stimulation. This review focuses on the molecular mechanisms of TLO formation and maintenance, the controversies surrounding the nature of the inducing events, and the functions of these structures in infection, transplantation and autoimmunity.

B lymphocyte, T lymphocyte, Th17 cell, antigen presenting cell, autoimmunity, chronic inflammation, human, immunopathology, immunoreactivity, immunostimulation, infection, lupus erythematosus, lymph node, lymphoid organ, nonhuman, organogenesis, review, signal transduction, spleen, tertiary lymphoid organ, tissue structure
dx.doi.org/10.1016/j.it.2012.04.006, hdl.handle.net/1765/39098
Trends in Immunology
Erasmus MC: University Medical Center Rotterdam

Neyt, K, Perros, F, Geurts van Kessel, C.H, Hammad, H, & Lambrecht, B.N.M. (2012). Tertiary lymphoid organs in infection and autoimmunity. Trends in Immunology (Vol. 33, pp. 297–305). doi:10.1016/j.it.2012.04.006