Avian influenza viruses are the precursors of human influenza A viruses. They may be transmitted directly from avian reservoirs, or infect other mammalian species before subsequent transmission to their human host. So far, avian influenza viruses have caused sporadic - yet increasingly more frequently recognized - cases of infection in humans. They have to adapt to and circulate efficiently in human populations, before they may trigger a worldwide human influenza outbreak or pandemic. Cross-species transmission of avian influenza viruses from their reservoir hosts - wild waterbirds - to terrestrial poultry and to humans is based on different modes of transmission and results in distinctive pathogenetic manifestations, which are reviewed in this paper.

Avian, Cross-species transmission, Human, Influenza, Pathogenesis, Zoonosis
dx.doi.org/10.4161/hv.8.1.18420, hdl.handle.net/1765/39207
Human Vaccines and Immunotherapeutics
Erasmus MC: University Medical Center Rotterdam

Reperant, L.A, Kuiken, T, & Osterhaus, A.D.M.E. (2012). Influenza viruses: From birds to humans. Human Vaccines and Immunotherapeutics (Vol. 8, pp. 97–106). doi:10.4161/hv.8.1.18420