Specific mutations within the hypervariable herpes simplex virus (HSV) gene thymidine kinase (TK) gene lead to acyclovir (ACV) resistance. To uncover the existence of latent ACV-resistant (ACV R) HSV-1, we determined the genetic and functional variability of the HSV-1 TK gene pool in paired trigeminal ganglia (TG) of 5 immunocompetent individuals. The latent virus pool consisted of a donor-specific HSV-1 quasispecies, including one major ACV-sensitive (ACV S) and multiple phylogenetic-related minor ACV S and ACV R TK variants. Contrary to minor variants, major TK variants were shared between paired TG. The data demonstrate the coexistence of phylogenetic-related ACV S and ACV R latent HSV-1 in human TG. © 2012 The Author.

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doi.org/10.1093/infdis/jis237, hdl.handle.net/1765/39255
Erasmus MC: University Medical Center Rotterdam

van Velzen, M, van Loenen, F.B, Meesters, R.J.W, de Graaf, M, Remeijer, L, Luider, T.M, … Verjans, G.M.G.M. (2012). Latent acyclovir-resistant herpes simplex virus type 1 in trigeminal ganglia of immunocompetent individuals. doi:10.1093/infdis/jis237