The severe acute respiratory syndrome (SARS) is responsible for the first pandemic of the 21st century. Within months after its emergence in Guangdong Province in mainland China, it had affected more than 8000 patients and caused 774 deaths in 26 countries on five continents. It illustrated dramatically the potential of air travel and globalization for the dissemination of an emerging infectious disease and highlighted the need for a coordinated global response to contain such disease threats. We review the cause, epidemiology, and clinical features of the disease.

*Disease Outbreaks, *Severe Acute Respiratory , Age Factors, Animals, Contact Tracing, Disease Reservoirs, Female, Humans, Male, Molecular Epidemiology, Multivariate Analysis, Prognosis, Risk Factors, SARS Virus/*isolation & purification, Syndrome/diagnosis/epidemiology/transmission/virology,
New England Journal of Medicine
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Erasmus MC: University Medical Center Rotterdam

Peiris, J.S.M, Yuen, K.Y, Osterhaus, A.D.M.E, & Stöhr, K. (2003). The severe acute respiratory syndrome. New England Journal of Medicine (Vol. 349, pp. 2431–2441). doi:10.1056/NEJMra032498