The aims of this srudy can be sUllllilalized as follows: 1. Analysis of the determinants of blood flow rate. The resistance to flow rate of catheters and dialyzers was studied and the influence of blood viscosity was analyzed. A method was investigated for the determination of blood flow rate by using a probe outside the blood line. 2. Analysis of the determinants of ultrafiltration and convective rranspon rate. The transmembrane pressure difference and the hydraulic permeability of dialyzers were determined as well as the change in hydraulic permeability over time. Funhermore, the 'sieving coefficients' were determined for a number of clinically relevant solutes. 3. Analysis of the determinants of the diffusive transpon rate. A mathematical model of combined convection and diffusion was developed and used to determine the diffusive mass transfer coefficiem of a number of solutes as a function of solute characteristics and operational conditions. 4. Application of the new knowledge in mathematical models in order to predict blood flow, ultrafiltration and solute clearance rates. 5. Developmem of guidelines for the performance of CAVHD therapy with respect to equipment, operational conditions and adjustment of drug dosage and additional therapy. 6. Description of the outcome of patients with acute renal failure, treated with CAVHD

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This study was financially supponed by the Dutch Kidney Foundation (Grants nr C88.821 and C89.0873), Hospal, MSD, Glaxo and Bayer. The printing of this thesis was financed by Roussel, which is gratefully acknowledged
M.A.D.H. Schalekamp (Maarten)
Erasmus University Rotterdam , Uitgeverij Eburon, Delft
Erasmus MC: University Medical Center Rotterdam

Vos, M. (1993, May 19). Continuous arteriovenous hemodiafiltration. Retrieved from