In the peripheral nervous system, large caliber axons are ensheathed and myelinated by Schwann cells. Myelin is crucial for a faster signal transduction along the nerve. Hence it is not surprising that defects in this myelination process cause serious neurological disease. Despite the medical importance of these cells, our understanding of the cellular and molecular mechanisms that control Schwann cell development and myelination is still incomplete. Continuous communication between Schwann cells and neurons is essential for the development, differentiation and myelination of peripheral nerves. Previous studies showed that LGI4 is a secreted protein that is crucial for myelination and might be a key player in this communication process. The main aim of this thesis is to elucidate the mechanism of LGI4 function in peripheral nerve myelination and to identify its interaction partners. Chapter 1 of this thesis presents an overview of the different types of cells in the peripheral nervous system with an emphasis on Schwann cell development and myelination.

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The studies described in this thesis were supported by grants from the BSIK Innovation programme “Stem Cells in Development and Disease” (SCDD, BSIK 03038),the Dutch government to the Netherlands Institute for Regenerative Medicine (NIRM, grant No. FES0908), VICI grant 918.66.616 and the European Union (NGIDD FP7 HEALTH-F2-2008-201535). Financial support by Erasmus MC for the publication of this thesis is gratefully acknowledged.
Erasmus MC: University Medical Center Rotterdam
D.N. Meijer (Dies)
Erasmus MC: University Medical Center Rotterdam

Kegel, L. (2013, April 10). Role and Specificity of LGI4-ADAM22 Interactions in Peripheral Nerve Myelination. Retrieved from