This study focuses on the effect of chemotherapy on endocrinopathies and the metabolic syndrome in adult survivors of childhood acute myeloid leukemia (AML). Endocrine function and metabolic syndrome were evaluated in 12 AML survivors, treated with chemotherapy, and in 9 survivors of myeloid leukemias treated with stem cell transplantation (SCT), after a median follow-up time of 20 years (range 9-31). In survivors treated with chemotherapy, no endocrinopathies or metabolic syndrome were present, although AMH and Inhibin B levels tended to be lower than in controls. In SCT survivors, pituitary deficiencies and metabolic syndrome were more frequent.

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Keywords Acute myeloid leukemia, Chemotherapy, Childhood cancer, Endocrine sequelae, Metabolic syndrome, Stem cell transplantation
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Journal Leukemia Research: clinical and laboratory studies
Blijdorp, K, van Waas, M, van der Lely, A-J, Pieters, R, van den Heuvel-Eibrink, M.M, & Neggers, S.J.C.M.M. (2013). Endocrine sequelae and metabolic syndrome in adult long-term survivors of childhood acute myeloid leukemia. Leukemia Research: clinical and laboratory studies, 37(4), 367–371. doi:10.1016/j.leukres.2012.12.008