Genetic genealogy comes of age: Perspectives on the use of deep-rooted pedigrees in human population genetics
In this article, we promote the implementation of extensive genealogical data in population genetic studies. Genealogical records can provide valuable information on the origin of DNA donors in a population genetic study, going beyond the commonly collected data such as residence, birthplace, language, and self-reported ethnicity. Recent studies demonstrated that extended genealogical data added to surname analysis can be crucial to detect signals of (past) population stratification and to interpret the population structure in a more objective manner. Moreover, when in-depth pedigree data are combined with haploid markers, it is even possible to disentangle signals of temporal differentiation within a population genetic structure during the last centuries. Obtaining genealogical data for all DNA donors in a population genetic study is a labor-intensive task but the vastly growing (genetic) genealogical databases, due to the broad interest of the public, are making this job more time-efficient if there is a guarantee for sufficient data quality. At the end, we discuss the advantages and pitfalls of using genealogy within sampling campaigns and we provide guidelines for future population genetic studies. © 2013 Wiley Periodicals, Inc.
|ancestry, genetic genealogy, genomic diversity, haploid markers, population history, sampling strategy, surname|
|Organisation||Erasmus MC: University Medical Center Rotterdam|
Larmuseau, M.H.D, Geystelen, A, van Oven, M, & Decorte, R. (2013). Genetic genealogy comes of age: Perspectives on the use of deep-rooted pedigrees in human population genetics . doi:10.1002/ajpa.22233