Human metapneumovirus (HMPV) is a member of the subfamily Pneumovirinae within the family Paramyxo- viridae. Other members of this subfamily, respiratory syncytial virus and avian pneumovirus, can be divided into subgroups on the basis of genetic or antigenic differences or both. For HMPV, the existence of different genetic lineages has been described on the basis of variation in a limited set of available sequences. We address the antigenic relationship between genetic lineages in virus neutralization assays. In addition, we analyzed the genetic diversity of HMPV by phylogenetic analysis of sequences obtained for part of the fusion protein (n = 84) and the complete attachment protein open reading frames (n = 35). On the basis of sequence diversity between attachment protein genes and the differences in virus neutralization titers, two HMPV serotypes were defined. Each serotype could be divided into two genetic lineages, but these did not reflect major antigenic differences.

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Keywords Amino Acid Sequence, Genetic Variation, HN Protein/genetics, Humans, Metapneumovirus/classification/*genetics/*immunology, Molecular Sequence Data, Open Reading Frames, Phylogeny, Viral Envelope Proteins, Viral Fusion Proteins/genetics, Viral Vaccines/immunology
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Journal Emerging Infectious Diseases - (Open Access)
Herfst, S, Sprong, L, Cane, P.A, Forleo-Neto, E, Osterhaus, A.D.M.E, Fouchier, R.A.M, … van den Hoogen, B.G. (2004). Antigenic and genetic variability of human metapneumoviruses. Emerging Infectious Diseases - (Open Access), 10(4), 658–666. Retrieved from