2013-04-16
Heart transplant survival in non-human primates : T cell-directed immunosuppressive therapy and regulatory T cells for promotion of heart transplant survival in non-human primates
Publication
Publication
Overleving na harttransplantatie: T cell-gerichtte immunosuppressieve therapie en regulatoire T cellen ter verbetering van de overleving na harttransplantatie in primaten
Heart transplantation significantly enhances the life expectancy of adult patients suffering heart failure, and infants born with malformations of their heart. However, there are many hurdles such as rejection of the transplanted organ, or side effects of the immunosuppressive drugs, that are yet to be overcome. This dissertation focuses on two components that may promote heart transplant survival, and survival of a transplanted organ in general. This Introduction reviews all the important components that are discussed in the thesis; it provides a general overview of the anatomy and function of the heart and the medical relevance of heart transplantation, the importance of non-human primate (NHP) transplant models to carry out the studies for this thesis, and the background of each research topic in relation to its medical relevance.
| Additional Metadata | |
|---|---|
| , , | |
| The work was financially supported by the Dutch Royal Academy of Science, the Prof. Michael van Vloten Fund and the Thomas E. Starzl Transplantation Institute of the University of Pittsburgh, by National Institutes of Health grants and by Sponsored Research Agreements between the University of Pittsburgh and Revivicor, Inc., Blacksburg, VA, by grants from the American Heart Association and the Starzl Transplantation Institute Joseph Patrick Fellowship. Baboons were provided by the Oklahoma University Health Sciences Center, Division of Animal Resources, Oklahoma, OK, USA. Cynomolgus monkeys were purchased from and provided by Alpha Genesis Inc, and the NIH NIAID colony, Yamassee, NC, USA. | |
| J.N.M. IJzermans (Jan) , D.K.C. Cooper (David) | |
| Erasmus University Rotterdam | |
| hdl.handle.net/1765/39669 | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
|
Dons, E. (2013, April 16). Heart transplant survival in non-human primates : T cell-directed immunosuppressive therapy and regulatory T cells for promotion of heart transplant survival in non-human primates . Retrieved from http://hdl.handle.net/1765/39669 |
|
