2002-07-26
Enteric administration of a live attenuated measles vaccine does not induce protective immunity in a macaque model
Publication
Publication
Vaccine , Volume 20 - Issue 23-24 p. 2906- 2912
To test the option of oral vaccination with a live attenuated measles vaccine (LAV), we have evaluated the potential of an orally administered enteric-coated tablet containing a candidate LAV (strain Leningrad-16, MV-L16). To this end three groups of two cynomolgus macaques each were vaccinated via different routes with 103.8TCID50MV-L16 vaccine: intramuscularly (i.m.), intraintestinally (i.i.) upon laparotomy and via enteric-coated tablets. Upon vaccination, MV-L16 could only be isolated from one of the i.m.-vaccinated monkeys and not from any of the other five. Both the i.m.-infected monkeys and one of the i.i.-infected monkeys developed a MV-specific serum antibody response. Also, MV-specific CD8+IFNγ-producing T cells could be demonstrated in all three monkeys that had seroconverted. Upon challenge with wild-type MV 1 year after vaccination, only these three monkeys proved to be protected. These data do not support the viability of the concept of oral vaccination with LAVs.
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| doi.org/10.1016/S0264-410X(02)00231-1, hdl.handle.net/1765/39710 | |
| Vaccine | |
| Organisation | Department of Virology |
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Stittelaar, K., de Swart, R., Vos, H., van Amerongen, G., Agafonov, A. P., Nechaeva, E. A., & Osterhaus, A. (2002). Enteric administration of a live attenuated measles vaccine does not induce protective immunity in a macaque model. Vaccine, 20(23-24), 2906–2912. doi:10.1016/S0264-410X(02)00231-1 |
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