1995
Short term fasting does not aggravate immunosuppression in harbour seals (Phoca vitulina) with high body burdens of organochlorines
Publication
Publication
Chemosphere , Volume 31 - Issue 10 p. 4289- 4306
Two groups of 11 harbour seals (Phoca vitulina) with different body burdens of organochlorines were subjected to an experimental 15-day fasting period, during which they lost an average 16.5% of their body weights. Blood levels of the most persistent organochlorines showed an approximate twofold increase, while levels of aryl hydrocarbon receptor-binding organochlorines remained largely unaffected. Few differences in immunological parameters were observed between the two dietary groups. Numbers of circulating lymphocytes dropped to about 65% of the initial values and NK cell activity showed a slight increase in both groups. Mitogen- and antigen-induced lymphoproliferative responses of the Baltic group of seals remained within normal ranges. These results suggest that relatively short-term fasting periods do not present an additional immunotoxicological risk to seals with high body burdens of organochlorines.
| Additional Metadata | |
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| doi.org/10.1016/0045-6535(95)00298-M, hdl.handle.net/1765/39812 | |
| Chemosphere | |
| Organisation | Department of Virology |
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de Swart, R., Ross, P., Timmerman, H., Hijman, W. C., de Ruiter, E. M., Liem, A. K. D., Brouwer, A., van Loveren, H., Reijnders, P. J. H., Vos, J.& Osterhaus, A. (1995). Short term fasting does not aggravate immunosuppression in harbour seals (Phoca vitulina) with high body burdens of organochlorines. Chemosphere, 31(10), 4289–4306.https://doi.org/10.1016/0045-6535(95)00298-M |
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