Benign prostatic hyperplasia (BPH) is the most common non-cancerous form of cell growth in men and usually begins with the formation of microscopic nodules in younger men. As BPH progresses, overgrowth occurs in the central area of the prostate, called the transition zone, which wraps around the urethra. The stromal component of the prostate is comprised by smooth muscle and connective tissue, while the epithelial component is primarily glandular. The relationship between the stromal and the epithelial component is approximately 2:1 in the normal prostate. In patients with BPH, the stromal to epithelial ratio increases to 5:1.

Additional Metadata
Keywords BPH, epidemiology, prostatic hyperplasia, urology
Promotor B.H.Ch. Stricker (Bruno) , J.L.H.R. Bosch (Ruud)
Publisher Erasmus University Rotterdam
Sponsor The author gratefully acknowledges all general practitioners participating in the IPCI database. Printing of this thesis was financially supported by Yamanouchi Europe.
ISBN 978-90-77595-80-0
Persistent URL
Verhamme, K.M.C. (2004, November 10). Epidemiology and management of symptomatic benign prostatic hyperplasia. Erasmus University Rotterdam. Retrieved from