2013-04-08
Elevated numbers of regulatory T cells, central memory T cells and class-switched B cells in cerebrospinal fluid of patients with anti-Hu antibody associated paraneoplastic neurological syndromes
Publication
Publication
Journal of Neuroimmunology , Volume 258 - Issue 1-2 p. 85- 90
Multi-parametric flow cytometry was used to study lymphocyte subsets and dendritic cells in paired blood and CSF samples from 11 newly diagnosed patients with progressive anti-Hu antibody associated paraneoplastic neurological syndromes (Hu-PNS), 9 patients with other inflammatory neurologic disorders (IND), and 12 patients with other non-inflammatory neurologic disorders (OND). Hu-PNS patients had elevated numbers of regulatory T cells, central memory T cells, class-switched B cells and dendritic cells in their CSF. These findings support the hypothesis that the immune system is locally activated in Hu-PNS, and suggests common etiological pathways between Hu-PNS and other inflammatory central nervous system disorders.
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| doi.org/10.1016/j.jneuroim.2013.02.006, hdl.handle.net/1765/39849 | |
| Journal of Neuroimmunology | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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de Jongste, A., de Graaf, M., van den Broek, P., Kraan, J., Smitt, P., & Gratama, J.-W. (2013). Elevated numbers of regulatory T cells, central memory T cells and class-switched B cells in cerebrospinal fluid of patients with anti-Hu antibody associated paraneoplastic neurological syndromes. Journal of Neuroimmunology, 258(1-2), 85–90. doi:10.1016/j.jneuroim.2013.02.006 |
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