2013-05-01
Precore and core promoter mutants are associated with higher HBeAg seroconversion but low disease remission rates in HBV patients treated with nucleos(t)ide analogues
Publication
Publication
Journal of Viral Hepatitis , Volume 20 - Issue 5 p. 322- 327
HBeAg seroconversion in HBV patients is considered an important event. We determined precore (PC) and base core promoter (BCP) mutations in 137 HBeAg-positive nucleos(t)ide analogues (NA) treated patients by INNO-LiPA HBV PreCore assay (Innogenetics). The majority of patients with nongenotype A had PC/BCP mutants present at baseline (P = 0.02). During 29 months of therapy, 45 patients achieved HBeAg seroconversion. Probability of HBeAg seroconversion was higher in patients with PC and/or BCP mutants (P = 0.01). After HBeAg seroconversion, patients with BCP mutants had more HBeAg relapse (P = 0.07), and PC mutants less often achieved HBV DNA < 2000 IU/mL (P = 0.07).
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| doi.org/10.1111/jvh.12033, hdl.handle.net/1765/39922 | |
| Journal of Viral Hepatitis | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Zoutendijk, R., Sonneveld, M., Reijnders, J., van Vuuren, H., Biesta, P., Hansen, B., … Janssen, H. (2013). Precore and core promoter mutants are associated with higher HBeAg seroconversion but low disease remission rates in HBV patients treated with nucleos(t)ide analogues. Journal of Viral Hepatitis, 20(5), 322–327. doi:10.1111/jvh.12033 |
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