As a direct result of the composition of our solar system, life on Earth is continuously exposed to regular geophysical cycles that impose temporal changes to the environment. To cope with these cyclic changes, and thus improve survival, organisms have acquired a timing mechanism that adjusts behavior, physiology, and metabolism to optimally adapt to their surroundings (Edery, 2000).

The research presented in this thesis was performed at the Department of Genetics of the Erasmus Medical Center in Rotterdam, The Netherlands. The Department is member of the Medical Genetics Centre South-West Netherlands (MGC). Research was carried out as part of the Netherlands Toxicogenomics Center and received financial support from the Netherlands Genomics Initiative (NGI)/Netherlands Organization for Scientific Research (NWO).
G.T.J. van der Horst (Gijsbertus)
Erasmus University Rotterdam
Erasmus MC: University Medical Center Rotterdam

Nijman, R. (2013, May 22). The Impact of the Circadian Clock on Toxic and Carcinogenic Responses: Its about time!. Retrieved from