Abstract

In at least 10% of newly diagnosed patients, HIV-1 variants harbouring resistance mutations in protease and reverse transcripase are detected. This thesis describes the impact of such resistance mutations on the transmission efficacy of HIV, the evolution of drug resistant HIV variants after transmission and the clinical impact of transmitted drug resistant viruses.

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The research described in this thesis was financially supported by the Dutch Aids fonds [grant 2007043] and partially performed at the University Medical Center Utrecht. Printing of this thesis was financially supported by ViiV HC Nederland, Virology Education, Merck Sharp & Dohme and Boehringer Ingelheim bv.
Erasmus MC: University Medical Center Rotterdam
C.A.B. Boucher (Charles)
hdl.handle.net/1765/40136
Erasmus MC: University Medical Center Rotterdam

Pingen, M. (2013, May 8). Transmission and Evolution of Drug Resistant HIV-1 Variants. Retrieved from http://hdl.handle.net/1765/40136