Extrathyroidal deiodination of T4 is the most important route for production of bioactive T3. This occurs predominantly in the liver, catalyzed by the microsomal type I deiodinase, which is also responsible for most of the degradation of the inactive rT 3. The liver is furthermore essential for the conjugation of iodothyronines with sulfate and glucuronic acid. This thesis deals with the connection between the various biochemical pathways of thyroid hormone metabolism. A better understanding of those metabolic routes involved in the regulation ofT 3 bioavailability helps to clarify the changes in the thyroid hormone economy induced by pathophysiological conditions. The successive Chapters II-VIII roughly reflect the chronological order of my experimental studies

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This work was supported by grant 900-540-191 from the Netherlands Organization for Scientific Research (NWO). The financial support from Organon Nederland BV for printing this thesis is gratefully acknowledged.
T.J. Visser (Theo)
Erasmus University Rotterdam
hdl.handle.net/1765/40209
Erasmus MC: University Medical Center Rotterdam

Rutgers, M. (1992, December 10). Thyroid hormone metabolism: importance of deiodination, conjugation and side chain modification. Retrieved from http://hdl.handle.net/1765/40209