Therapeutic aspects of gonococcal and non-gonococcal urethritis

The investigations described in this thesis can be divided into two parts. In the first part, the clinical efficacies of enoxacin (a new qninolone), cefodizime (a third generation parenteral cephalosporin) and ceftetrame (a new oral cephalosporin) were assessed in patients with gonococcal urethritis. In the second part, the therapeutic effectiveness of ciprofloxacin (a new quinolone) and roxithromycin (a new macrolide) were assessed in patients with NGU. Susceptibilities of N. gonorrhoeae and C. trachomatis to different antibiotics were also assessed. N. gonorrhoeae and C. rrachomatis strains that were isolated from patients before and after treatment were also tested for possible resistance formation to the particular antibiotic used for treatment. These strains were also typed wherever possible. Side-effects and laboratory abnormalities caused by these trial drugs were also strictly monitored and critically evaluated.