Plant-derived recombinant human collagen: A Strategic approach for generating safe human ECM-based scaffold

Almost two decades have passed since the concept and the potential of tissue engineering were proposed by Dr. Robert Langer and Dr. Joseph Vacanti. During this time period, tissue engineering research has evolved from basic research to applied research and even to clinical application. At the current stage, efficacy and safety become extremely important issues for the translation of tissue engineering strategies to the clinic. As one of the key elements, scaffold materials play a very important role in tissue engineering. Scaffolds serve not only as templates for tissue formation but also as sources of cues that actively induce stem cell differentiation and tissue regeneration. It is well accepted that scaffolds should mimic aspects of the extracellular matrix (ECM) and should not cause a too large foreign body reaction for effective repair strategies. [...]

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