Solid organ transplantation has dramatically increased the survival of both adult and children suffering from end-stage organ failure and improved the quality of life of these patients.With the introduction of calcineurin-inhibitors (CNIs) the short-term survival of transplant recipients improved even further. Presently, more than 90% of the immunosuppressive protocols in organ transplantation have CNIs incorporated as the primary immunosuppressant, resulting in CNIs being the mainstay of immunosuppressive therapy.

Additional Metadata
Keywords children, organ transplantation, pharmacokinetics
Promotor D. Tibboel (Dick) , G. Koren (Gideon)
Publisher Erasmus University Rotterdam
Persistent URL
Gijsen, V.M.G.J. (2013, May 30). Tacrolimus: The balance between good and evil Pharmacogenetics in pediatric solid organ transplant recipients. Erasmus University Rotterdam. Retrieved from