Cardiovascular disease risk in adults with spastic bilateral cerebral palsy
Journal of Rehabilitation Medicine , Volume 45 - Issue 9 p. 866- 872
Objective: To explore: (i) cardiovascular disease risk factors and the 10-year clustered risk of a fatal cardiovascular event in adults with spastic bilateral cerebral palsy; and (ii) relationships between the 10-year risk and body fat, aerobic fitness and physical activity. Design: Cross-sectional study. Subjects: Forty-three adults with spastic bilateral cerebral palsy without severe cognitive impairment (mean age 36.6 years (standard deviation 6); 27 men). Methods: Biological and lifestyle-related risk factors and the 10-year risk according to the Systematic Coronary Risk Evaluation (SCORE) were assessed. Relationships were studied using multivariable linear regression analysis. Results: The following single risk factors were present: hypertension (n = 12), elevated total cholesterol (n = 3), low high-density lipoprotein cholesterol (n = 5; all men), high-risk waist circumference (n = 11), obesity (body mass index; n = 5; all men), reduced aerobic fitness (on average 80% of reference values), reduced level of everyday physical activity (on average 78% of reference values) and smoking (n=9). All participants had a 10-year risk <1%. Corrected for gender, participants with higher waist circumference (β = 0.28; p = 0.06) or body mass index (β=0.25; p = 0.08) tended to have a higher 10-year risk. Conclusion: In this relatively young adult sample of people with spastic bilateral cerebral palsy several single cardiovascular disease risk factors were present. The 10-year fatal cardiovascular disease risk was low, and higher body fat tended to be related to higher 10-year risk.
|cardiiovascular diseases, cardiology|
|Journal of Rehabilitation Medicine|
|Epub ahead of print|
|Organisation||Erasmus MC: University Medical Center Rotterdam|
van der Slot, W.M.A, Roebroeck, M.E, Nieuwenhuijsen, C, Bergen, M.P, Stam, H.J, Burdorf, A, & van den Berg-Emons, H.J.G. (2013). Cardiovascular disease risk in adults with spastic bilateral cerebral palsy. Journal of Rehabilitation Medicine, 45(9), 866–872. doi:10.2340/16501977-1185