Gastric cancer is the final step in a multi-stage cascade triggered by long-standing inflammatory conditions (particularly Helicobacter pylori infection) resulting in atrophic gastritis and intestinal metaplasia: these lesions represent the cancerization field in which (intestinal-type) gastric cancer develops. Intraepithelial neoplasia is consistently recognized as the phenotypic bridge between atrophic/metaplastic lesions and invasive cancer. This paper addresses the epidemiology, pathology, molecular profiling, and clinical management of advanced precancerous gastric lesions.

Gastric cancer, Gastritis, Gastritis staging, Precancerous gastric lesions,
Best Practice and Research in Clinical Gastroenterology
Erasmus MC: University Medical Center Rotterdam

Rugge, M, Capelle, L.G, Cappellesso, R, Nitti, D, & Kuipers, E.J. (2013). Precancerous lesions in the stomach: From biology to clinical patient management. Best Practice and Research in Clinical Gastroenterology, 27(2), 205–223. doi:10.1016/j.bpg.2012.12.007