Gastric cancer is the final step in a multi-stage cascade triggered by long-standing inflammatory conditions (particularly Helicobacter pylori infection) resulting in atrophic gastritis and intestinal metaplasia: these lesions represent the cancerization field in which (intestinal-type) gastric cancer develops. Intraepithelial neoplasia is consistently recognized as the phenotypic bridge between atrophic/metaplastic lesions and invasive cancer. This paper addresses the epidemiology, pathology, molecular profiling, and clinical management of advanced precancerous gastric lesions.

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Best Practice and Research in Clinical Gastroenterology
Erasmus MC: University Medical Center Rotterdam

Rugge, M., Capelle, L., Cappellesso, R., Nitti, D., & Kuipers, E. (2013). Precancerous lesions in the stomach: From biology to clinical patient management. Best Practice and Research in Clinical Gastroenterology, 27(2), 205–223. doi:10.1016/j.bpg.2012.12.007