Statins, systemic inflammation and risk of death in COPD: The Rotterdam study
Background: Studies suggest that statins decrease mortality in COPD patients but it is unknown which patients might benefit most. Objectives: We investigated whether statins were associated with reduced mortality in COPD patients and whether effects differed according to baseline high-sensitivity C-reactive protein (hsCRP) concentration, a marker of systemic inflammation. Methods: This nested case-control study was part of the Rotterdam Study, a prospective population-based cohort study among 7983 subjects ≥ 55 years. Using automated pharmacy records, we evaluated statin use of 363 cases (COPD patients who died during follow-up of 17 years) with 2345 age and sex matched controls (COPD patients who survived the follow-up period of the index case). Results: Compared to never use, long-term statin use (>2 years) was associated with a 39% decreased risk of death in COPD patients. Stratified according to the level of systemic inflammation, long-term statin use was associated with a 78% reduced mortality if hsCRP level > 3 mg/L, versus a non significant 21% reduced mortality if hsCRP level ≤ 3 mg/L. Conclusions: Statin use is associated with a beneficial effect on all-cause mortality in COPD, depending on the baseline level of systemic inflammation.
|Keywords||aged, article, case control study, cholesterol blood level, chronic obstructive lung disease, controlled study, disease exacerbation, female, follow up, human, long term care, lung carcinoma, lung emphysema, major clinical study, male, mortality, pneumonia, prescription, priority journal, prospective study, respiratory tract inflammation, spirometry, survival, treatment duration|
|Persistent URL||dx.doi.org/10.1016/j.pupt.2012.10.008, hdl.handle.net/1765/40806|
|Journal||Pulmonary Pharmacology and Therapeutics|
Lahousse, L, Loth, D.W, Joos, G.F, Hofman, B, Leufkens, H.G.M, Brusselle, G.G, & Stricker, B.H.Ch. (2013). Statins, systemic inflammation and risk of death in COPD: The Rotterdam study. Pulmonary Pharmacology and Therapeutics, 26(2), 212–217. doi:10.1016/j.pupt.2012.10.008