Long-term outcome of kidney transplantation in patients with a urinary conduit: A case-control study
International Urology and Nephrology , Volume 45 - Issue 2 p. 405- 411
Purpose: To study the short- and long-term outcomes of kidney transplantation in patients with a bladder augmentation or urinary diversion compared to patients with a kidney transplantation in a normal functional bladder. Patients and methods: Between January 2000 and March 2011, 13 patients received 16 grafts into a reconstructed urinary tract. We performed a retrospective case-control study and matched each patient to 4 controls for donor and recipient gender and year of transplantation. Results: Short- and long-term complications of kidney transplantation occurred in 12 patients, varying from urinary tract infections to medical hospitalization with or without surgical or radiological intervention. In 5 patients, a percutaneous nephrostomy (PCN) was placed followed by surgical re-intervention. In three patients, the grafts failed as a result of chronic rejection and were re-transplanted. There was no graft loss as a result of surgical complications or the reconstructed urinary tract. One-year patient and graft survival was 100 %. After five years, all patients were alive and seven of nine grafts (77.8 %) were functioning. Mean follow-up time was 4.3 years. Among the controls, 55 grafts were transplanted in 52 patients. Ten patients received a PCN. Five patients needed surgical re-intervention. In three patients, transplantectomy was performed for ongoing rejection. Three patients were re-transplanted. One patient had a failing graft 7.5 years post-transplantation and became dialysis dependent. Conclusion: Kidney transplantation in patients with a reconstructed urinary tract has an increased complication rate. Nevertheless, the long-term results are comparable to patients with a normal urinary bladder.
|Kidney transplantation, Reconstructed urinary tract, Urological complications|
|International Urology and Nephrology|
|Organisation||Erasmus MC: University Medical Center Rotterdam|
Slagt, I.K.B, IJzermans, J.N.M, Alamyar, M, Verhagen, P.C.M.S, Weimar, W, Roodnat, J.I, & Terkivatan, T. (2013). Long-term outcome of kidney transplantation in patients with a urinary conduit: A case-control study. International Urology and Nephrology, 45(2), 405–411. doi:10.1007/s11255-013-0395-1