This paper reviews the mechanisms believed to be responsible for myocardial ischaemia and the mode of action of calcium antagonist drugs. The clinical management of patients with myocardial ischaemia is discussed in the context of current knowledge about patho-physiology and drug action.

0 (Calcium Channel Blockers), 0 (Pyridines), 21829-25-4 (Nifedipine), Acute Disease, Angina Pectoris/*drug therapy, Animals, Calcium Channel Blockers/pharmacology/*therapeutic use, Coronary Circulation/drug effects, Coronary Disease/*drug therapy/physiopathology, Hemodynamic Processes/drug effects, Human, Myocardium/metabolism, Nifedipine/pharmacology/*therapeutic use, Oxygen Consumption/drug effects, Pyridines/*therapeutic use, Swine
hdl.handle.net/1765/4103
Postgraduate Medical Journal: an international peer-reviewed journal of continuing professional development
Erasmus MC: University Medical Center Rotterdam

Hugenholtz, P.G, de Jong, J.W, Verdouw, P.D, & Serruys, P.W.J.C. (1983). Nifedipine for angina and acute myocardial ischemia. Postgraduate Medical Journal: an international peer-reviewed journal of continuing professional development, 59, 40–58. Retrieved from http://hdl.handle.net/1765/4103