Cytomegalovirus (CMV)-carrying individuals have significantly higher levels of effector memory and late memory T lymphocytes in their blood than non-carriers. To date, it is well recognized that the central nervous system is subjected to active immunosurveillance, as evidenced by the presence of central memory T cells in cerebrospinal fluid (CSF) of healthy individuals. In order to investigate whether levels of effector memory and late memory T cells were also increased in the CSF of CMV-carrying individuals, we characterized CD4+and CD8+T-cell subsets in CSF and blood of both groups. Effector memory and late memory T cells were only rarely seen in CSF, which was similar in CMV carriers and non-carriers. In conclusion, there was no demonstrable difference in the numbers of CSF effector memory and late memory T cells between CMV seronegative and CMV seropositive individuals. Copyright

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doi.org/10.1002/cyto.b.21073, hdl.handle.net/1765/41063
Cytometry Part B - Clinical Cytometry
Erasmus MC: University Medical Center Rotterdam

de Jongste, A.H.C, de Graaf, M.T, van den Broek, P.D.M, Kraan, J, Smitt, P.A, & Gratama, J.W. (2013). Effector memory and late memory T cells accumulate in the blood of CMV-carrying individuals but not in their cerebrospinal fluid. Cytometry Part B - Clinical Cytometry, 84(4), 218–221. doi:10.1002/cyto.b.21073