Prevalence of actinic keratosis and its risk factors in the general population: The rotterdam study
Limited data are available on the prevalence and risk factors of actinic keratoses (AKs). Within the Rotterdam Study, full-body skin examinations were performed among participants aged 45 years or older to estimate the age-and sex-standardized prevalence of AK and its associated risk factors. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated for associations between risk factors and the presence of 1-3, 4-9, and ≥10 AKs. Of the 2,061 inspected cohort members (mean age 72 years), 21% had 1-3, 9% had 4-9, and 8% had ≥10 AKs. AK prevalence was 49% (95% CI: 46-52%) for men and 28% (26-31%) for women. Male gender, older age, light pigmentation status, severe baldness, skin wrinkling, and high tendency for sunburn were significantly associated with extensive actinic damage (≥10 AKs) in the multivariate analyses. Especially bald males were at an increased risk of severe actinic skin damage (adjusted OR=7.0 (3.8-13.1)). The prevalence of AK is very high, especially among elderly bald males. The prevention and management of AK is a true challenge for patients, physicians, and health-care policymakers.
|Keywords||actinic keratosis, adult, aged, alopecia, article, female, human, major clinical study, male, prevalence, priority journal, risk factor, skin defect, skin examination, skin pigmentation, sunburn, wrinkle|
|Persistent URL||dx.doi.org/10.1038/jid.2013.134, hdl.handle.net/1765/41268|
|Journal||The Journal of Investigative Dermatology|
Flohil, S.C, van der Leest, R.J.T, Dowlatshahi, E.A, Hofman, A, de Vries, E, & Nijsten, T.E.C. (2013). Prevalence of actinic keratosis and its risk factors in the general population: The rotterdam study. The Journal of Investigative Dermatology, 133(8), 1971–1978. doi:10.1038/jid.2013.134