Objectives: To determine whether the 6-minute walk test (6MWT) is predictive of peak oxygen consumption (Vo2peak) and whether the 6MWT is a clinically applicable alternative to cardiopulmonary exercise testing (CPET) in ambulatory adolescents and young adults with cerebral palsy (CP). Design: Cross-sectional. Setting: University hospital and rehabilitation centers. Participants: Adolescents and young adults with CP (N=41) classified in Gross Motor Function Classification System (GMFCS) level I or II. Interventions: Not applicable. Main Outcome Measures: The covered distance during 6 minutes was measured with a 6MWT. The Vo2peak was obtained with CPET on a cycle ergometer. Results: Univariate linear regression analysis was used to study the relationship between the outcomes of both tests. A multiple linear regression analysis was performed to determine whether Vo2peak could be predicted by the 6MWT, sex, body mass, and GMFCS level. A significant relationship (P<.01) was found between the outcomes of the 6MWT and CPET, with an explained variance of 21%. The multiple linear regression analysis showed an explained variance of 58% and a standard error of estimate (SEE) corresponding to 18% of the mean Vo2peak. Conclusions: The 6MWT is poorly related to Vo2peak in ambulatory adolescents and young adults with CP. Because of a high SEE, the multiple regression model did not allow for prediction of Vo2peak from the 6MWT in ambulatory adolescents and young adults with CP.

Cardiopulmonary exercise test, Physical fitness, Rehabilitation
dx.doi.org/10.1016/j.apmr.2013.05.023, hdl.handle.net/1765/41288
Archives of Physical Medicine and Rehabilitation
Erasmus MC: University Medical Center Rotterdam

Slaman, J, Dallmeijer, A.J, Stam, H.J, Russchen, H, Roebroeck, M.E, & van den Berg-Emons, H.J.G. (2013). The Six-Minute Walk Test Cannot Predict Peak Cardiopulmonary Fitness in Ambulatory Adolescents and Young Adults With Cerebral Palsy. Archives of Physical Medicine and Rehabilitation, 94(11), 2227–2233. doi:10.1016/j.apmr.2013.05.023