This thesis describes research performed on several generalized autoimmune diseases with the main focus on primary Sjögren’s syndrome. Interferon type I has been implicated in the pathogenesis of these diseases and will be introduced in this chapter together with other important immune factors in these diseases such as BAFF and Th17 cells. In this chapter first a general introduction about the immune system will be given, followed by introduction about Interferon type I, BAFF, Th17, Sjögren’s syndrome and finally the other two studied autoimmune diseases.

, ,
The studies were financially supported by the Netherlands Organization for Scientific Research (NWO) Mosaic grant and the Dutch Arthritis Foundation. The printing of the thesis was supported by J.E. Jurriaanse Stichting, Nationale Vereniging Sjögrenpatiënten and the Dutch Arthritis Foundation
H.A. Drexhage (Hemmo) , P.M. van Hagen (Martin)
Erasmus University Rotterdam
Erasmus MC: University Medical Center Rotterdam

Brkic, Z. (2013, September 19). Interferon Type I Driven Immune Activation in Generalized Autoimmune Diseases. Retrieved from