Comparison of long-term outcomes in STEMI and NSTE-ACS after coronary stent placement: An analysis in a real world BMS and des population
Background/Objectives: The prognostic difference between STEMI and NSTE-ACS after coronary stent placement remains unclear. We aimed to compare the short- and long-term event rates in patients presenting with ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation acute coronary syndrome (NSTE-ACS) after percutaneous coronary intervention (PCI) with either bare-metal stents (BMS) or drug-eluting stents (DES). Methods: Between 2000 and 2005 a total of 1749 STEMI and 1921 NSTE-ACS patients received either a BMS or DES in consecutive real world cohorts. Descriptive statistics and multivariate survival analyses were applied to compare the event rates in STEMI and NSTE-ACS during 4 years follow-up. Results: NSTE-ACS patients had significantly higher clinical and angiographic risk profiles at baseline and were treated with less optimal medical therapy during follow-up. At 4 years follow-up, all-cause mortality was significantly higher in STEMI compared to NSTE-ACS after coronary stent placement (17.4% vs. 14.3%; HR 1.60, 95% CI 1.24-2.07). In a landmark analysis no difference was seen in all-cause mortality among STEMI en NSTE-ACS between 1 month and 4 years follow-up (HR 1.10, 95% CI 0.81-1.51). Cardiac death was more prevalent in STEMI patients, while the 4-year cumulative incidences of any myocardial infarction, any coronary revascularization, target lesion revascularization and definite stent thrombosis were similar in both ACS groups. Conclusions: Patients presenting with STEMI have a worse long-term prognosis compared to NSTE-ACS after coronary stent placement, due to higher short-term death rates. However, after the first month STEMI and NSTE-ACS patients have a comparable long-term survival.
|Keywords||NSTE-ACS, Outcome, PCI, STEMI, Stent|
|Persistent URL||dx.doi.org/10.1016/j.ijcard.2012.05.064, hdl.handle.net/1765/41423|
|Journal||International Journal of Cardiology|
van Leeuwen, M.A.H, Daemen, J, van Mieghem, N.M, de Boer, S.P.M, Boersma, H, van Geuns, R.J.M, … Serruys, P.W.J.C. (2013). Comparison of long-term outcomes in STEMI and NSTE-ACS after coronary stent placement: An analysis in a real world BMS and des population. International Journal of Cardiology, 167(5), 2082–2087. doi:10.1016/j.ijcard.2012.05.064