2013-10-04
Reassortments and Mutations Modulating Virulence and Transmission of Influenza A Virus
Publication
Publication
Reassorteringen en mutaties bepalend voor virulentie en transmissie van influenza A virus
Influenza A virus is a member of the Orthomyxoviridae family. The influenza A viruses are classified on the basis of antigenic properties of the glycoproteins hemagglutinin (HA) and neuraminidase (NA) into 17 HA subtypes (H1-H17) and 10 NA subtypes (N1-N10) [1-3]. These different subtypes of HA and NA are used in influenza A virus nomenclature, to discriminate viruses based on the surface glycoproteins (e.g. H5N1, H3N2). All subtypes with the exception of H17N10 circulate in wild birds, which are considered their natural reservoir [4]. The H17N10 subtype has recently been isolated from bats, raising the possibility that birds are not the exclusive influenza virus reservoir. Influenza A virus is a single-stranded negative-sense segmented RNA virus, with a genome consisting of eight gene segments, that can encode up to 16 proteins [5-9] (Fig 1a).
| Additional Metadata | |
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| , , | |
| Viroclinics Biosciences BV, GR instruments, Drost Loosdrecht BV, Greiner Bio-One, IKS international | |
| R.A.M. Fouchier (Ron) , A.D.M.E. Osterhaus (Albert) | |
| Erasmus University Rotterdam | |
| hdl.handle.net/1765/41491 | |
| , | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Schrauwen, E. (2013, October 4). Reassortments and Mutations Modulating Virulence and Transmission of Influenza A Virus. Retrieved from http://hdl.handle.net/1765/41491 |
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| Additional Files | |
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| 3833_Schrauwen, Eefje Johanna Adriana.jpg Cover Image , 1mb | |
| Stellingen Schrauwen.pdf , 18kb | |
