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F. Liu (Fan), B. Wen (Bei) and M.H. Kayser (Manfred)

2013-06-01

Colorful DNA polymorphisms in humans

Publication

Publication

Seminars in Cell and Developmental Biology , Volume 24 - Issue 6-7 p. 562- 575

In this review article we summarize current knowledge on how variation on the DNA level influences human pigmentation including color variation of iris, hair, and skin. We review recent progress in the field of human pigmentation genetics by focusing on the genes and DNA polymorphisms discovered to be involved in determining human pigmentation traits, their association with diseases particularly skin cancers, and their power to predict human eye, hair, and skin colors with potential utilization in forensic investigations.

Additional Metadata
Keywords DNA marker, DNA polymorphism, Gilbert disease, adaptation, allele, cancer incidence, chromatin, chromosome, cutaneous melanoma, disease association, environment, evolutionary adaptation, eye color, frameshift mutation, gene interaction, gene mutation, genetic association, genetic polymorphism, genetic variability, genetics, genotype, hair color, heterozygote, human, hydroxylation, iris, malignant lentigo, melanocyte, melanogenesis, melanoma, melanosome, natural selection, phenotype, phenotypic variation, pigmentation, predictive value, recessive inheritance, review, rickets, sexual selection, single nucleotide polymorphism, skin cancer, skin color, skin pigmentation, solar radiation, spinal dysraphism, stop codon, ultraviolet radiation, vitamin D deficiency
Persistent URL doi.org/10.1016/j.semcdb.2013.03.013, hdl.handle.net/1765/41538
Journal Seminars in Cell and Developmental Biology
Organisation Erasmus MC: University Medical Center Rotterdam
Citation
Liu, F., Wen, B., & Kayser, M. (2013). Colorful DNA polymorphisms in humans. Seminars in Cell and Developmental Biology (Vol. 24, pp. 562–575). doi:10.1016/j.semcdb.2013.03.013


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