2013-10-01
Delirium in the acute phase after stroke and the role of the apolipoprotein e gene
Publication
Publication
American Journal of Geriatric Psychiatry , Volume 21 - Issue 10 p. 935- 937
Objective: To study the association between the epsilon 4 allele of apolipoprotein E (APOEε4) and delirium in a stroke population. Methods: 527 consecutive stroke patients were screened for delirium during the first week of admission with the confusion assessment method. In three hundred fifty-three patients genomic DNA isolation was available. Results: The incidence of delirium after stroke in the 353 patients was 11.3%. There was no association between APOEε4 and delirium. Even after adjustment for IQCODE, stroke localization, stroke subtype, stroke severity, infection, and brain atrophy no association was found (odds ratio: 0.9; 95% confidence interval: 0.4e2.1). Delirium did not last longer in patients with an APOEε4 allele compared to patients without an APOEε4 allele (median: 5.6 days [range: 1-21] versus median: 4.6 days [range: 1-15], p = 0.5). Conclusion: There was no association between the presence of an APOEε4 allele and the occurrence of delirium in the acute phase after stroke.
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| doi.org/10.1016/j.jagp.2013.01.068, hdl.handle.net/1765/41563 | |
| American Journal of Geriatric Psychiatry | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Oldenbeuving, A. W., de Kort, P., Kappelle, J., van Duijn, C., & Roks, G. (2013). Delirium in the acute phase after stroke and the role of the apolipoprotein e gene. American Journal of Geriatric Psychiatry, 21(10), 935–937. doi:10.1016/j.jagp.2013.01.068 |
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