This paper introduces reversed phase free ion selective radiotracer extraction (RP-FISRE) as a new tool to assess the stability of metal complexes, as illustrated by the assessment of the stability of [177Lu]Lu-DOTA-octreotate. To this end, the TUDelft-developed FISRE, where the released metal is column-retained and the complex eluted, was changed into RP-FISRE, where the complex is column-retained and the released metal is eluted. This change in the approach allows for studies to be performed with high stability complexes. This paper presents RP-FISRE, the strength of the radiotracer approach, and the first-ever kddata on the release of177Lu from [177Lu]Lu-DOTA-octreotate.

article, chemical analysis, chemical composition, chemical structure, complex formation, controlled study, dynamics, elution, extraction and extracts, iodination, isotope labeling, light scattering, mass spectrometry, molecular stability, priority journal, reversed phase free ion selective radiotracer extraction, thermodynamics,
Applied Radiation and Isotopes
Erasmus MC: University Medical Center Rotterdam

van der Meer, A, Breeman, W.A.P, & Wolterbeek, B. (2013). Reversed phase free ion selective radiotracer extraction (RP-FISRE): A new tool to assess the dynamic stabilities of metal (-organic) complexes, for complex half-lives spanning six orders of magnitude. Applied Radiation and Isotopes, 82, 28–35. doi:10.1016/j.apradiso.2013.06.021