This paper introduces reversed phase free ion selective radiotracer extraction (RP-FISRE) as a new tool to assess the stability of metal complexes, as illustrated by the assessment of the stability of [177Lu]Lu-DOTA-octreotate. To this end, the TUDelft-developed FISRE, where the released metal is column-retained and the complex eluted, was changed into RP-FISRE, where the complex is column-retained and the released metal is eluted. This change in the approach allows for studies to be performed with high stability complexes. This paper presents RP-FISRE, the strength of the radiotracer approach, and the first-ever kddata on the release of177Lu from [177Lu]Lu-DOTA-octreotate.

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Applied Radiation and Isotopes
Erasmus MC: University Medical Center Rotterdam

van der Meer, A, Breeman, W.A.P, & Wolterbeek, B. (2013). Reversed phase free ion selective radiotracer extraction (RP-FISRE): A new tool to assess the dynamic stabilities of metal (-organic) complexes, for complex half-lives spanning six orders of magnitude. Applied Radiation and Isotopes, 82, 28–35. doi:10.1016/j.apradiso.2013.06.021