Systemic and coronary hemodynamic effects of the new dihydropyridine calcium antagonist nisoldipine were studied over a 30-minute period in 12 patients with angina pectoris. Previously instituted beta-blocker therapy was continued. Nisoldipine was administered in an intravenous bolus of 6 micrograms/kg over 3 minutes. Heart rate increased as mean aortic pressure and systemic vascular resistance decreased in all patients. Cardiac output increased significantly, from 5.8 +/- 0.3 to 7.9 +/- 0.5 liters/min, 10 minutes after nisoldipine infusion. These trends were maintained over the 30-minute observation period. Coronary sinus blood flow increased from 103 +/- 11 to 139 +/- 13 ml/min immediately after nisoldipine, but had returned to the control level by 30 minutes, as had the reduction in coronary vascular resistance. Myocardial oxygen consumption and heart rate-systolic blood pressure product did not change significantly. Nisoldipine is a potent peripheral and coronary vasodilator free of major myocardial depressant effects after acute intravenous administration. The systemic vasodilatory effects appear to outlast the coronary effects over 30 minutes.

0 (Adrenergic beta-Antagonists), 0 (Lactates), 21829-25-4 (Nifedipine), 50-21-5 (Lactic Acid), 63675-72-9 (Nisoldipine), Adrenergic beta-Antagonists/pharmacology, Adult, Coronary Circulation/drug effects, Coronary Vessels/*drug effects, Female, Hemodynamic Processes/*drug effects, Human, Lactates/metabolism, Lactic Acid, Male, Middle Aged, Myocardial Infarction/drug therapy, Myocardium/metabolism, Nifedipine/*analogs & derivatives/pharmacology/therapeutic use, Nisoldipine, Oxygen Consumption/drug effects
The American Journal of Cardiology
Erasmus MC: University Medical Center Rotterdam

Soward, A.L, de Feyter, P.J, Hugenholtz, P.G, & Serruys, P.W.J.C. (1986). Coronary and systemic hemodynamic effects of intravenous nisoldipine. The American Journal of Cardiology, 58, 1199–1203. Retrieved from