2013-06-19
Embryonic Stem Cell Proteins and MicroRNAs in the Etiology of Germ Cell Cancer
Publication
Publication
Embryonale stamcel eiwitten en microRNAs in de etiologie van kiemcelkanker
In the early 1980s, a population of unique cells was isolated from the inner cell mass (ICM) of the mouse pre-implantation embryo named embryonic stem (ES) cells. These cells were generated by removing the ICM from pre-implantation blastocysts. The resulting cells were found to be pluripotent and showed unrestricted proliferative potential. Human ES cell lines have now been derived in many labs from totipotent cells of the early mammalian embryo and are capable of unlimited, undifferentiated proliferation in vitro. Essential characteristics of ES cells include: a) derivation from the pre-implantation embryo, b) prolonged (undifferentiated) proliferation and c) stable developmental potential to form derivatives of all three embryonic germ layers even after prolonged culture [6]. These unique properties of ES cells make them exceptionally valuable for cell replacement therapy and regenerative medicine, defining their potential clinical applications.
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| , , | |
| L.H.J. Looijenga (Leendert) | |
| The research described in this thesis was funded by the Dutch Cancer Society. Printing of this thesis was financially supported by: Dutch cancer society J.E.Jurriaanse Stichting Novartis Pharma B.V. | |
| Erasmus University Rotterdam | |
| hdl.handle.net/1765/50078 | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Eini, R. (2013, June 19). Embryonic Stem Cell Proteins and MicroRNAs in the Etiology of Germ Cell Cancer. Retrieved from http://hdl.handle.net/1765/50078 |
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| Additional Files | |
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| 3778_Eini-Ronak.jpg Cover Image , 1mb | |
| Thesis-Ronak-Eini-219819-Propositions.pdf , 8kb | |
