The family of Herpesviridae is highly disseminated in the animal world, with a wide range of host species. Because most animal species have at least one herpesvirus, the number of herpesviruses in nature is likely to exceed by far the 138 currently identifi ed members. To date, eight human herpesviruses have been identifi ed: human herpesvirus 1 to 8 (HHV1-HHV8). They are classifi ed on basis of their cell tropism and genome organization into subfamilies of Alpha-, Beta-, and Gammaherpesvirinae (Table 1). In addition to causing productive infections, a key feature of herpesviruses is their ability to establish latency. This non-productive phase lasts for the life time of the host, is characterized by a silent viral infection with intermittent reactivations, commonly clinical unapparent, resulting in intermittent shedding of infectious virus and spread throughout the population.

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A.D.M.E. Osterhaus (Albert)
The studies presented in this thesis were carried out at the Department of Virology, Erasmus MC, Rotterdam, the Netherlands. The research for this thesis was performed within the framework of the Erasmus Postgraduate School Molecular Medicine. Publication of this thesis was fi nancially supported by: Postgraduate School Molecular Medicine, Erasmus University Rotterdam, JE Jurriaanse Stichting and eBioscience.
Erasmus University Rotterdam
Erasmus MC: University Medical Center Rotterdam

van Velzen, M. (2013, June 21). Herpes Simplex Virus Type 1 Infection: Features of immune surveillance and antiviral resistance. Retrieved from http://hdl.handle.net/1765/50320