Immunoregulatory and antitumor effects of interferon-γ

IFN-y was one of the first cytokines produced by recombinant DNA technology. After the production of recombinant DNA derived mouse and human IFN-y, recombinant DNA derived rat IFN-y became available. With this species-specific cytokine it has become possible to study biological effects of IFN-y in rats. Compared to the mouse model, the rat model is more suitable to study activities of IFN-y in tumor and organ transplantation experiments, since these experiments are technically far less demanding in rats. In this thesis multiple biological effects of rRIFN-y are studied in transplantation and tumor experiments in rats.