Clinical studies on fibrinolysis inhibitors synthesized by the liver

In this thesis studies on congenital and acquired disorders of the fibrinolytic system, with emphasis on the inhibitors of the fibrinolytic system, are described. This was initiated to obtain more information on the fibrinolytic system, and to obtain insight into the mechanism of enhancement of fibrinolysis in patients with liver disease. In chapter 2, a concise review on the fibrinolytic system, on the role of the liver in the regulation of the fibrinolytic system and an overview on the literature on fibrinolysis in liver disease are given. In the other chapters biochemical and clinical studies on fibrinolysis inhibitors are reported. In the last two chapters we report investigations on the fibrinolytic system in patients with liver cirrhosis