The Pseudomonas flora and tobramycin pharmacokinetics in patients with cystic fibrosis

The aim of the study was to establish whether the composition of the flora of P. aeruginosa in the lungs of individual patients is subject to changes or whether it remains constant over time. The number of different serotypes per patient ranged from one to three, and pyocin and phage typing showed no marked differences between strains of the same serotype. In general, patients whose sputum yielded more than one type harbored these in several samples. An exacerbation of the chronic respiratory infection did not affect the composition of the flora. long term observations showed that a given type or types tended to recur supporting the conclusion that the composition of the pseudomonas flora in CF remains fairly constant over time