1988-10-19
Cellular mechanisms in the generation of the low T3 syndrome
Publication
Publication
The results from the work of Krenning and Docter in our laboratory, as discussed in previous sections, led to the hypothesis that inhibition of transmembraneous transport of iodothyronines, could be a major factor in inducing the hormonal changes in the low T 3 syndrome. A three-pool model of distribution and metabolism ofT 4, T 3 and rT 3 was used for kinetic analysis. Two conditions in which a low T 3 syndrome is known to originate, were studied: caloric deprivation and oral administration of propranolol. Chapter 2 deals with alterations in kinetic parameters during caloric deprivation in 10 obese subjects. The same parameters were assessed in six normal non-obese L-T4 replaced male students before and during D- propranolol treatment. The results obtained in this latter group are presented in chapter 3. In chapter 4 early serum disappearance and computed liver uptake of thyroxine in humans during caloric deprivation and D-propranolol administration are discussed. In addition, both parameters were assessed immediately after intravenous administration of fructose, a manoeuvre by which a prompt and significant fall in liver A TP is induced. In chapter 5 the results from the above mentioned sections are summarized.
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Erasmus University Rotterdam | |
G. Hennemann (George) | |
hdl.handle.net/1765/51063 | |
Organisation | Erasmus MC: University Medical Center Rotterdam |
van der Heyden, J. T. M. (1988, October 19). Cellular mechanisms in the generation of the low T3 syndrome. Retrieved from http://hdl.handle.net/1765/51063 |