Colposcopy in diagnosis and treatment of cervical intraepithelial neoplasia (CIN)

AIMS OF THE STUDIES 1. To investigate the diagnostic value of colposcopy under research conditions, in patients with an indication for colposcopy. (Wouter M. Huisman) 2. To investigate the possibility of accurately predicting histopathology by means of the colposcopic impression, when a standard set of diagnostic criteria is used. (Wouter M. Huisman) 3. To investigate the predictive contribution of colposcopy in grading CIN and in the recognition of human papilloma virus (HPV) infections within the standard facilities of the University Hospital Dijkzigt-Rotterdam in the routine cytologic, colposcopic and histopathologic evaluation of selected patients with cervical smears suggestive of cervical intraepithelial neoplasia. (J.A. Wijnen) 4. To investigate in a prospective randomized study the possible effects of systemic folic acid supplementation on the cytologic, colposcopic and histopathologic manifestations of cervical intraepithelial neoplasia. (J.A. Wijnen) 5. To investigate in a prospective randomized study the therapeutic effectiveness and side-effects of laser- or cryotherapy in patients with cervical intraepithelial neoplasia. (J.A. Wijnen).