2004-03-24
Cerebral Small Vessel Disease in Dementia and Depression: a prospective population-based MRI study
Publication
Publication
Cerebrale microangiopathie bij dementie en depressie: Een prospectieve MRI studie onder de algemene populatie
Abstract
Cerebral white matter lesions and asymptomatic brain infarcts are common in elderly people. These brain lesions are thought to result from cerebral small vessel disease, and their presence and severity increase with age and the presence of arterial hypertension. There is widespread belief that cerebral small vessel disease plays a role in the aetiology of dementia. Small vessel disease is commonly regarded as the primary pathology in subcortical ischemic vascular dementia, one of the subtypes of vascular dementia. Furthermore, vascular factors, including cerebral small vessel disease, are increasingly recognized to be involved in the aetiology of Alzheimer’s disease.8 However, there is hardly any evidence from prospective population-based studies to support these notions.
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| , , , , , | |
| M.M.B. Breteler (Monique) , P.J. Koudstaal (Peter) | |
| Erasmus University Rotterdam | |
| The work presented in this thesis was conducted at the Department of Epidemiology & Biostatistics in close collaboration with the Department of Neurology of the Erasmus Medical Center, Rotterdam. The Rotterdam Scan Study was supported by grants from the Netherlands Organisation for Scientifi c Research, and the Netherlands Heart Foundation. Financial support from the study on homocysteine was provided by the EU BIOMED Demonstration Project, which paid for the homocysteine assays. The author gratefully acknowledges the collaboration with the Department of Radiology, University Hospital Groningen (Prof.dr. M. Oudkerk), the Department of Psychiatry & Neuropsychology, University Maastricht (Prof.dr. J. Jolles), the Clinical Trial Service Unit, University of Oxford, United Kingdom (Prof.dr. R. Clarke), the Department of Neurology, VU Medical Center, Amsterdam (Prof.dr. Ph. Scheltens), the Department of Radiology, VU Medical Center, Amsterdam (Prof.dr. F. Barkhof), the Biomedical Imaging Group Rotterdam, a collaboration between the Department of Radiology and Medical Informatics, Erasmus Medical Center, Rotterdam (Dr. H.A. Vrooman), and the Regional Institute for Ambulatory Mental Health and the general practitioners of Rotterdam and Zoetermeer. The Department of Epidemiology & Biostatistics and the Department of Neurology of the Erasmus Medical Center, Rotterdam, the Netherlands Organisation for Scientifi c Research (NWO) and Internationale Stichting Alzheimer Onderzoek contributed in the production costs of this thesis. | |
| hdl.handle.net/1765/51241 | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Prins, N. (2004, March 24). Cerebral Small Vessel Disease in Dementia and Depression: a prospective population-based MRI study. Retrieved from http://hdl.handle.net/1765/51241 |
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