2014-02-25
Genetic Program Controlled by LDBl, TALl and GATA2 in Hemangioblast Development
Publication
Publication
Het genetisch programma aangestuurd door LDBl, TALl en GATA2 in hemangioblast ontwikkeling
Abstract
The ontogeny of the mammalian hematopoietic system is characterized by two waves of hematopoietic progenitors during embryonic development. The first 'primitive' wave takes place in the YS blood islands at around embryonic day (E)7.5 of gestation in the mouse conceptus and produces primitive erythrocytes, megakaryocytes and macrophages. Around E I 0 of gestation, hematopoiesis shifts to an intraembryonic site, the aorta gonadmesonephros (AGM) region, where definitive hematopoietic precursors and the first long-term hematopoietic stem cells (HSC) are generated. Definitive hematopoietic precursors migrate to the liver to further develop into definitive hematopoietic stem cells (HSC) and mature in all blood lineages. From E 12 until birth, the liver becomes the main site of hematopoietic development, aiming to support the growing midgestation foetus. After birth and during all adult life, hematopoiesis occurs in the bone marrow.
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| , | |
| F.G. Grosveld (Frank) | |
| Erasmus University Rotterdam | |
| The studies presented in this thesis were performed in the Department of Cell Biology of the Erasmus MC in Rotterdam, The Netherlands. The department is a member of the Medisch Genetisch Centrum Zuid-West Nederland (MGC). | |
| hdl.handle.net/1765/51477 | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Martella, A. (2014, February 25). Genetic Program Controlled by LDBl, TALl and GATA2 in Hemangioblast Development. Retrieved from http://hdl.handle.net/1765/51477 |
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