The aim of this thesis is to gain greater insight into how TNF produces its effect in current cancer treatment with the overall goal of improving TNF-based cancer treatment. TNF response as well as toxicity takes place at the vascular level where cytokines can have effect on the endothelial cells. We describe matters concerning this interaction as well as related experiments that have been conducted in our laboratory.

Additional Metadata
Keywords TNF, cancer therapy, sarcomas, tumor necrosis factor
Promotor A.M.M. Eggermont (Alexander)
Publisher Erasmus University Rotterdam
Persistent URL
Lans, T. (2004, February 19). Understanding and improving TNF-based cancer therapy. Erasmus University Rotterdam. Retrieved from