Aging of the population is accompanied by many challenges, such as the maintenance of health and quality of life during older age. An important aspect of living longer is that old age is related to disease and loss of functions. The loss of brain functions poses a large problem in older age. Changes that occur in the brain can already be visualized when no symptoms or clinical disease are apparent. Magnetic resonance imaging (MRI) is often used to visualize subtle brain changes. The subclinical brain changes can however be used as markers of future clinical disease. Furthermore, subclinical, subtle changes in brain function can cause considerable discomfort in daily living.

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Keywords brain aging, Alzheimer disease, neurology, quality of life, cognitive decline, dementia
Promotor A. Hofman (Albert) , A. van der Lugt (Aad)
Publisher Erasmus University Rotterdam
Sponsor The work described in this thesis was conducted at the department of Epidemiology in collaboration with the department of Neurology at the Erasmus MC University Medical Center. The Rotterdam Study is supported by the Erasmus MC University Medical Center and Erasmus University Rotterdam, the Netherlands Organization for Scientific Research (NWO), the Netherlands Organization for Health Research and Development (ZonMw), The Research Institutate for Diseases in the Elderly (RIDE), the Ministry of Education, Culture and Science, the Ministry of Health, Welfare and Sports, the European Commission (DG XII) and the Municipality of Rotterdam. Financial support for publication of this thesis was kindly provided by the departments of Epidemiology & Radiology of the Erasmus MC University Medical Center Rotterdam, Erasmus University Rotterdam, and Alzheimer Nederland.
ISBN 978-94-6259-240-7
Persistent URL hdl.handle.net/1765/51548
Hoogendam, Y.Y. (2014, June 25). The Role of Brain Aging in Cognition and Motor Function. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/51548