Bridging the Gap in Relation to Nerve Injury

Abstract

The title of this thesis has been chosen after careful reflection. The different meanings reflect the research performed in this thesis:

• Nerve regeneration after bridging a large nerve defect is an important subject of this thesis.
• The second interpretation of this title should be sought in the translational aspect of this thesis. We tried to implement the use of Bone Marrow Stromal Cells (BMSCs) in nerve reconstruction in a conduit often used in clinical setting. A bench to bedside approach!
• The third interpretation refers to the bridge between experimental and human research. In this thesis both types of studies have been conducted to answer research questions related to nerve injury and one aspect of clinical follow-up, i.e. cold intolerance!