2013
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism
Publication
Publication
Nature Genetics , Volume 45 - Issue 1 p. 76- 82
Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.
| Additional Metadata | |
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| doi.org/10.1038/ng.2477, hdl.handle.net/1765/54116 | |
| Nature Genetics | |
| Organisation | Department of Medical Microbiology and Infectious Diseases |
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Horikoshi, M., Yaghootkar, H., Mook-Kanamori, D., Sovio, U., Taal, R., Hennig, B. J., … Kieß, W. (2013). New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. Nature Genetics, 45(1), 76–82. doi:10.1038/ng.2477 |
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